RESEARCH
Immunological prevention of cancer
The aim of this project is to inhibit carcinogenesis using vaccines
and other immunological approaches.
As a model of individuals at high risk of cancer we are using
HER-2/neu transgenic mice , which spontaneously develop mammary
carcinomas, and other transgenic and knockout models.
Gene immunotherapy of cancer
Tumor cells transduced with genes coding for cytokines and
surface antigens are used as therapeutic vaccines to
stimulate the immune response against tumor and metastasis
growth.
Molecular and cellular biology of human musculo-skeletal
sarcomas
We study the molecular alterations of human rhabdomyosarcoma
and other musculo-skeletal sarcomas, to dissect the mechanisms
leading to unrestricted cell growth and to the inhibition of
terminal differentiation. We have also developed a transgenic/knockout mouse that
spontaneously develops pelvic rhabdomyosrcomas, allowing the study
of early events in the natural history of rhabdomyosarcoma
See our recent publications for further
details.
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